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Beilstein J Nanotechnol. 2012;3:556-63. Epub 2012 Jul 25.

Nanolesions induced by heavy ions in human tissues: Experimental and theoretical studies.

Author information

  • 1Frankfurt Institute for Advanced Studies (FIAS), Ruth-Moufang-Str. 1, 60438 Frankfurt am Main, Germany ; Institut für Theoretische Physik, Johann Wolfgang Goethe-Universität, Max-von-Laue-Str. 1, 60438 Frankfurt am Main, Germany.

Abstract

The biological effects of energetic heavy ions are attracting increasing interest for their applications in cancer therapy and protection against space radiation. The cascade of events leading to cell death or late effects starts from stochastic energy deposition on the nanometer scale and the corresponding lesions in biological molecules, primarily DNA. We have developed experimental techniques to visualize DNA nanolesions induced by heavy ions. Nanolesions appear in cells as "streaks" which can be visualized by using different DNA repair markers. We have studied the kinetics of repair of these "streaks" also with respect to the chromatin conformation. Initial steps in the modeling of the energy deposition patterns at the micrometer and nanometer scale were made with MCHIT and TRAX models, respectively.

KEYWORDS:

DNA repair, Monte Carlo simulations, heavy ions, microdosimetry, nanolesions, radiation-induced nanostructures

PMID:
23019551
[PubMed]
PMCID:
PMC3458601
Free PMC Article

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