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  • PMID: 23018473 was deleted because it is a duplicate of PMID: 23567388
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Am J Geriatr Psychiatry. 2013 Sep;21(9):906-14. doi: 10.1016/j.jagp.2013.01.021. Epub 2013 Feb 6.

The effect of subsyndromal symptoms of depression and white matter lesions on disability for individuals with mild cognitive impairment.

Author information

  • 1Center for Imaging of Neurodegenerative Diseases, Veterans Administration Medical Center, San Francisco, CA; Department of Psychiatry, University of California, San Francisco, CA. Electronic address: scottm@lppi.ucsf.edu.

Abstract

OBJECTIVE:

To assess the effect of subsyndromal symptoms of depression (SSD) on ratings of disability for individuals with mild cognitive impairment (MCI).

METHODS:

Data from 405 MCI participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI) study were analyzed. Participants were evaluated at baseline and at 6-month intervals over 2 years. Severity of depressive symptoms was rated utilizing the Geriatric Depression Scale. Disability was assessed utilizing the Functional Assessment Questionnaire (FAQ). Other clinical variables included white matter lesion (WML) and intracranial brain (ICV) volumes derived from magnetic resonance imaging, ratings of overall cognitive function (Alzheimer's Disease Assessment Scale, ADAS), and apolipoprotein E (ApoE) status. Demographic variables included age, education, and gender.

RESULTS:

SSD individuals had a lower volume of WML and higher frequency of ApoE ε4 alleles than nondepressed participants but the two groups did not differ with respect to other clinical or demographic variables. At baseline, SSD individuals were 1.77 times more likely to have poorer FAQ scores than individuals with no symptoms of depression after controlling for the effect of cognitive functioning, ICV, WML, and ApoE status. The presence of SSD at baseline was not associated with a poorer course of disability outcomes, cognitive functioning, or conversion to dementia over 24 months.

CONCLUSIONS:

SSD demonstrated a significant impact on disability for MCI individuals, who are also at high risk for functional limitations related to neurodegenerative disease. Therefore, the treatment of SSD may represent a significant avenue to reduce the burden of disability in this vulnerable patient population.

Copyright © 2013 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.

KEYWORDS:

ApoE; dementia; disability; longitudinal; mild cognitive impairment; subsyndromal depression; subthreshold depression; white matter lesions

PMID:
23567388
[PubMed - indexed for MEDLINE]
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