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Am J Transplant. 2013 Jan;13(1):36-44. doi: 10.1111/j.1600-6143.2012.04283.x. Epub 2012 Sep 27.

Leptin deficiency modulates allograft survival by favoring a Th2 and a regulatory immune profile. [corrected].

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  • 1Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, Brazil.

Erratum in

  • Am J Transplant. 2013 Aug;13(8):2231.


Leptin, an adipose-secreted hormone, links metabolism and immunity. Our aim was to determine whether leptin affects the alloimmune response. We used an allogeneic skin transplant model as a means to analyze the allograft immune response in Lep(ob/ob) and wild-type mice. Leptin deficiency results in an increased frequency of Treg and Th2 cells and a prolonged graft survival. These effects of leptin deficiency indicate the importance of leptin and obesity in modulating the allograft immune responses. Our data suggest a possible explanation for the increased susceptibility of hyperleptinemic obese patients to acute and chronic graft rejection.

© Copyright 2012 The American Society of Transplantation and the American Society of Transplant Surgeons.

[PubMed - indexed for MEDLINE]
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