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Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2012 Aug;29(4):687-90, 696.

[Tail-suspended model simulating mouse oocytes maturation inhibited with microgravity].

[Article in Chinese]

Author information

  • 1College of Animal Science, South China Agriculture University, Guangzhou 510642, China.

Abstract

We studied the effects of simulated microgravity on mouse oocytes maturation, and analyzed whether the tail-suspended model can be applied to investigate simulated microgravity effects on reproductive processes in female mice. Mouse oocytes were cultured in vitro with microgravity simulated by a rotating wall vessel bioreactor and by tail-suspended model, and the maturation rate of the mouse oocytes in the two models were examined in vivo. The maturation rate of mouse oocytes cultured in simulated microgravity was 8.93%, and that was 72.33% in 1g gravity. In ratio, oocyte maturation rate had no significant difference between the rotational group and control group. Microgravity simulated by the tail-suspended model inhibited mouse oocytes maturation and increased the rate of oocytes abnormity. The maturation rate of tail-suspended mouse oocytes was 14.54%, which was significantly lower than that of control group. Tail-suspended model should be an ideal model to investigate simulated microgravity effects on reproductive processes of female mice.

PMID:
23016417
[PubMed - indexed for MEDLINE]
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