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Beilstein J Org Chem. 2012;8:841-9. Epub 2012 Jun 6.

Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors.

Author information

  • 1Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China ; Shenzhen Shengjie Biotech Co., Ltd., Shenzhen 518055, China.

Abstract

Sant-75 is a newly identified potent inhibitor of the hedgehog pathway. We designed a diversity-oriented synthesis program, and synthesized a series of Sant-75 analogues, which lays the foundation for further investigation of the structure-activity relationship of this important class of hedgehog-pathway inhibitors.

KEYWORDS:

Sant-75; chemical diversity; diversity-oriented; hedgehog pathway; inhibitor; synthesis

PMID:
23015832
[PubMed]
PMCID:
PMC3388872
Free PMC Article

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