Copper-catalyzed intramolecular direct amination of sp2 C-H bonds for the synthesis of N-aryl acridones

Chem Commun (Camb). 2012 Nov 7;48(86):10678-80. doi: 10.1039/c2cc35425j.

Abstract

A copper-catalyzed approach for the synthesis of N-aryl acridones via sp(2) C-H bond amination using air as oxidant under neutral conditions is disclosed. This reaction not only provides a complementary method for synthesizing medicinally important acridones, but also offers a new strategy for sp(2) C-H bond amination.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acridones / chemical synthesis
  • Acridones / chemistry*
  • Amination
  • Carbon / chemistry
  • Catalysis
  • Copper / chemistry*
  • Hydrogen / chemistry
  • Oxidation-Reduction

Substances

  • Acridones
  • Carbon
  • Copper
  • Hydrogen