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World J Surg Oncol. 2012 Sep 25;10:198. doi: 10.1186/1477-7819-10-198.

Chromosomal structural analysis in carcinoma of the gallbladder.

Author information

  • 1Department of General Surgery Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221 005, India.

Abstract

BACKGROUND:

The etiopathogenesis of gallbladder cancer is still unknown. Both environmental and patient factors have been incriminated in its cause. That it is found in pockets of epidemiological distribution raises an issue of genetic changes associated with it. The aim of this study was to find out the chromosomal changes in gallbladder cancer.

METHODS:

Lymphocyte cell culture was carried out on blood of gallbladder cancer patients to determine chromosomal banding abnormalities. Native PAGE was also evaluated to analyze lactate dehydrogenase (LDH), superoxide dismutase (SOD) and catalase enzyme activity from the same blood of gallbladder cancer patients.

RESULTS:

Out of 30 gallbladder cancer patients, 4 male showed breakage on the long arm of chromosome 1 while only one male patient showed the translocation from the long arm of chromosome 4 to the long arm of chromosome 6 in a male patient.

CONCLUSION:

The aberrations found in our study may suggest underlying genetic predisposition for the development of gallbladder cancer. They can act as a marker for gallbladder cancer, which needs further study.

PMID:
23009611
[PubMed - indexed for MEDLINE]
PMCID:
PMC3506564
Free PMC Article

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