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Macromol Biosci. 2012 Nov;12(11):1524-33. doi: 10.1002/mabi.201200137. Epub 2012 Sep 24.

Preparation of pixantrone/poly(γ-glutamic acid) nanoparticles through complex self-assembly for oral chemotherapy.

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  • 1School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.

Abstract

A facile and green approach is reported to construct pixantrone/poly(γ-glutamic acid) nanoparticles (PIX/γ-PGA NPs) as an oral drug delivery system through the complex self-assembly of polyelectrolyte γ-PGA and the anticancer drug pixantrone dimaleate (PDM). The complex self-assembly behavior is investigated in detail. The results demonstrate that PDM can interact with γ-PGA to conveniently form NPs and the size of NPs can be controlled by adjusting the solution volume ratio of PDM to γ-PGA. These NPs illustrate their pH-dependent release behavior, efficient cellular uptake and enhanced drug efficacy through an in vitro release study, flow cytometry, CLSM analysis and the MTT assay. In summary, PIX/γ-PGA NPs may serve as a promising oral drug delivery system for cancer therapy.

Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

PMID:
23008063
[PubMed - indexed for MEDLINE]
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