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Bipolar Disord. 2012 Nov;14(7):749-55. doi: 10.1111/bdi.12000. Epub 2012 Sep 21.

Cognitive decline in elderly bipolar disorder patients: a follow-up study.

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  • 1GGZ inGeest, Amsterdam, The Netherlands. s.schouws@ggzingeest.nl

Abstract

OBJECTIVE:

Older individuals with bipolar disorder may exhibit greater cognitive decline over time compared to mentally healthy elderly individuals. We aimed to investigate neurocognitive performance in bipolar disorder over a period of two years.

METHODS:

A comprehensive neuropsychological test battery was applied at baseline and two years later to 65 euthymic elderly outpatients with bipolar disorder (mean age = 68.35, range: 60-90 years) and to a demographically comparable sample of 42 healthy elderly controls. A general linear model was used to measure changes over time for the two groups. The impact of baseline illness characteristics on intra-individual change in neurocognitive performance within the bipolar group was studied by using logistic regression analysis.

RESULTS:

At baseline and at follow up, bipolar disorder patients performed worse on all neurocognitive measures compared to the healthy elderly group. However, there was no significant group-by-time interaction between the bipolar disorder patients and the comparison group.

CONCLUSIONS:

Although older bipolar disorder patients have worse cognitive function than normal controls, they did not have greater cognitive decline over a period of two years.

© 2012 John Wiley and Sons A/S.

PMID:
22998105
[PubMed - indexed for MEDLINE]
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