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J Virol. 2012 Oct;86(20):11405-6.

Genome sequence of a novel HIV-1 circulating recombinant form 54_01B from Malaysia.

Author information

  • 1Centre of Excellence for Research in AIDS, Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Abstract

We report here the first novel HIV-1 circulating recombinant form (CRF) 54_01B (CRF54_01B) isolated from three epidemiologically unlinked subjects of different risk groups in Malaysia. These recently sampled recombinants showed a complex genome organization composed of parental subtype B' and CRF01_AE, with identical recombination breakpoints observed in the gag, pol, and vif genes. Such a discovery highlights the ongoing active generation and spread of intersubtype recombinants involving the subtype B' and CRF01_AE lineages and indicates the potential of the new CRF in bridging HIV-1 transmission among different risk groups in Southeast Asia.

PMID:
22997423
[PubMed - indexed for MEDLINE]
PMCID:
PMC3457179
Free PMC Article
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