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ChemMedChem. 2012 Nov;7(11):1915-20. doi: 10.1002/cmdc.201200363. Epub 2012 Sep 20.

A facile synthesis of novel bis-(indolyl)-1,3,4-oxadiazoles as potent cytotoxic agents.

Author information

  • 1Department of Chemistry, Birla Institute of Technology and Science, Pilani-333031, Rajasthan (India). dalipk@bits-pilani.ac.in.

Abstract

A recipe for potency: A novel series of bis(indolyl)-1,3,4-oxadiazoles was prepared from the corresponding hydrazide-hydrazones via iodobenzene diacetate-promoted oxidative cyclization. Evaluation against a panel of human cancer cell lines revealed that some derivatives possess potent cytotoxicity with tunable selectivity for different cancer types.

Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

KEYWORDS:

alkaloids; bis(indoles); cancer; cytotoxic agents; natural product derivatives

PMID:
22997171
[PubMed - indexed for MEDLINE]
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