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J Occup Environ Med. 2012 Oct;54(10):1214-23. doi: 10.1097/JOM.0b013e31826e27f1.

A road map toward a globally harmonized approach for occupational health surveillance and epidemiology in nanomaterial workers.

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  • 1IST Institut universitaire romand de Santé au Travail Institute for Work and Health, Université de Lausanne + Genève, Lausanne, Switzerland.



Few epidemiological studies have addressed the health of workers exposed to novel manufactured nanomaterials. The small current workforce will necessitate pooling international cohorts.


A road map was defined for a globally harmonized framework for the careful choice of materials, exposure characterization, identification of study populations, definition of health endpoints, evaluation of appropriateness of study designs, data collection and analysis, and interpretation of the results.


We propose a road map to reach global consensus on these issues. The proposed strategy should ensure that the costs of action are not disproportionate to the potential benefits and that the approach is pragmatic and practical.


We should aim to go beyond the collection of health complaints, illness statistics, or even counts of deaths; the manifestation of such clear endpoints would indicate a failure of preventive measures.

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