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Zhongguo Zhong Yao Za Zhi. 2012 Jun;37(11):1564-9.

[Identification of hydrolysates and alcoholysates of aconitum alkaloids].

[Article in Chinese]

Author information

  • 1China Pharmaceutical University, Nanjing 210009, China. wangff666@126.com

Abstract

OBJECTIVE:

To identify products decomposed in high temperature water and alcohol from diester alkaloids such as aconitum alkaloid, in order to study their transformation regularity.

METHOD:

Structures of multiple converted products were determined by analyzing on multistage mass spectrometry of known compounds and literature searching.

RESULT:

Benzaconine and pyraconitine were the major hydrolysates, while pyraconitine and ethoxy-aconitine were the major alcoholysates from diester alkaloids.

CONCLUSION:

Pyraconitine alkaloids, as pyrolytic products, are not related to the type of solvent. 8-ethoxy-aconitine alkaloids, as alcoholysates, are related to the type of solvent. This study identifies multiple converted products from alkaloids and summarizes mass spectrometry fragmentation regularity by LC-MS, laying a firm foundation for studies on the transformation of toxic diester alkaloids contained in aconitum and providing a basis for studies on the transformation of alkaloids contained in aconitum during boiling.

PMID:
22993981
[PubMed - indexed for MEDLINE]

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