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Clin Vaccine Immunol. 2012 Nov;19(11):1889-93. doi: 10.1128/CVI.00298-12. Epub 2012 Sep 19.

Evaluation of immunostimulatory activities of synthetic mannose-containing structures mimicking the β-(1->2)-linked cell wall mannans of Candida albicans.

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  • 1Department of Pulmonary Diseases and Clinical Allergology, University of Turku, Turku, Finland.

Abstract

Immunostimulatory properties of synthetic structures mimicking the β-(1→2)-linked mannans of Candida albicans were evaluated in vitro. Contrary to earlier observations, tumor necrosis factor (TNF) production was not detected after stimulation with mannotetraose in mouse macrophages. Divalent disaccharide 1,4-bis(α-D-mannopyranosyloxy)butane induced TNF and some molecules induced low levels of gamma interferon (IFN-γ) in human peripheral blood mononuclear cells (PBMC).

PMID:
22993407
[PubMed - indexed for MEDLINE]
PMCID:
PMC3491550
Free PMC Article
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