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Clin Pharmacol Ther. 2012 Oct;92(4):417-9. doi: 10.1038/clpt.2012.131.

Individualized dosing with anesthetic agents.

Author information

  • 1Department of Anesthesia, Stanford University School of Medicine, Stanford, California, USA. hlemmens@stanford.edu

Abstract

The development of fundamental pharmacokinetics and pharmacodynamics concepts has enabled anesthesiologists to choose and dose anesthetic agents on a rational basis. The application of these concepts to a variety of clinical scenarios and patient populations makes it possible to individualize the dose, thereby decreasing the risk of complications. As more knowledge is gained about the sometimes profound differences in drug response, empirical dosing such as in milligrams per kilogram of total body weight is disappearing from the anesthesia specialty.

PMID:
22992669
[PubMed - indexed for MEDLINE]
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