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Neurosci Lett. 2012 Oct 24;528(2):180-4. doi: 10.1016/j.neulet.2012.08.066. Epub 2012 Sep 7.

Occludin dislocation in brain capillary endothelium of rats with bile duct ligation induced cholestasis.

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  • 1Department of Neurosurgery, School of Medicine, University of Patras, Patras, Greece.


The present study used a rat model with bile duct ligation to examine the effect of cholestasis, to the localization of occludin in brain capillary endothelium by means of electronic microscopy. The results demonstrated a dislocation of occludin away from the tight junction sites of brain endothelial cells. A significant increase of the occludin-interendothelial cleft distance was demonstrated in the midbrain and the cerebellum samples but not in the frontal cortex, compared to the control group samples. These findings imply a brain region selective derangement of occludin in response to liver disease.

Copyright © 2012. Published by Elsevier Ireland Ltd.

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