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Biochim Biophys Acta. 2013 Jan;1829(1):63-8. doi: 10.1016/j.bbagrm.2012.08.010. Epub 2012 Sep 6.

Promoter clearance by RNA polymerase II.

Author information

  • 1Department of Molecular Genetics, Cleveland Clinic, Cleveland, OH 44195, USA. lused@ccf.org

Abstract

Many changes must occur to the RNA polymerase II (pol II) transcription complex as it makes the transition from initiation into transcript elongation. During this intermediate phase of transcription, contact with initiation factors is lost and stable association with the nascent transcript is established. These changes collectively comprise promoter clearance. Once the transcript elongation complex has reached a point where its properties are indistinguishable from those of complexes with much longer transcripts, promoter clearance is complete. The clearance process for pol II consists of a number of steps and it extends for a surprisingly long distance downstream of transcription start. This article is part of a Special Issue entitled: RNA polymerase II Transcript Elongation.

Copyright © 2012 Elsevier B.V. All rights reserved.

PMID:
22982364
[PubMed - indexed for MEDLINE]
PMCID:
PMC3529798
Free PMC Article
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