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Biochim Biophys Acta. 2013 Jan;1829(1):169-73. doi: 10.1016/j.bbagrm.2012.08.004. Epub 2012 Sep 6.

The eukaryotic transcriptional machinery regulates mRNA translation and decay in the cytoplasm.

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  • 1Department of Molecular Microbiology, Technion-Israel Institute of Technology, Haifa, Israel.

Abstract

In eukaryotes, nuclear mRNA synthesis is physically separated from its cytoplasmic translation and degradation. Recent unexpected findings have revealed that, despite this separation, the transcriptional machinery can remotely control the cytoplasmic stages. Key to this coupling is the capacity of the transcriptional machinery to "imprint" the transcript with factors that escort it to the cytoplasm and regulate its localization, translation and decay. Some of these factors are known transcriptional regulators that also function in mRNA decay and are hence named "synthegradases". Imprinting can be carried out and/or regulated by RNA polymerase II or by promoter cis- and trans-acting elements. This article is part of a Special Issue entitled: RNA polymerase II Transcript Elongation.

Copyright © 2012 Elsevier B.V. All rights reserved.

PMID:
22982191
[PubMed - indexed for MEDLINE]
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