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Endocrinol Nutr. 2012 Oct;59(8):487-90. doi: 10.1016/j.endonu.2012.06.005. Epub 2012 Sep 13.

Vitamin B(12) in type 2 diabetic patients treated with metformin.

[Article in English, Spanish]

Author information

  • 1Servicio de Medicina Interna, Hospital Ciudad de Coria, Coria, Cáceres, España. jm.calvo@orangemail.es

Abstract

OBJECTIVE:

To test vitamin B12 plasma levels in type 2 diabetic patients treated with metformin in our area.

METHODS:

A cross-sectional, observational study of consecutive type 2 diabetic patients on drug treatment attending an internal medicine outpatient clinic.

RESULTS:

One hundred and nine patients (81 treated with metformin) were enrolled into the study. Mean time on metformin treatment was 43.5 months and mean drug dose was 1,779 mg/day. Patients treated with metformin had significantly lower vitamin B(12) plasma levels (393.5 vs. 509 pg/mL, P = .0008). Seven (8.6%) of 81 patients treated with metformin and none of the 28 patients not treated with the drug had vitamin B(12) plasma levels lower than 197 pg/mL. No correlation was found between vitamin B12 plasma levles and metformin treatment time or dosage.

CONCLUSIONS:

In type 2 diabetic patients, treatment with metformin is associated to lower vitamin B12 plasma levels. Vitamin B12 deficiency associated with metformin is relatively common in our area.

Copyright © 2012 SEEN. Published by Elsevier Espana. All rights reserved.

PMID:
22981397
[PubMed - indexed for MEDLINE]
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