Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Trends Parasitol. 2012 Nov;28(11):457-65. doi: 10.1016/j.pt.2012.07.005. Epub 2012 Sep 11.

The design and interpretation of laboratory assays measuring mosquito transmission of Plasmodium.

Author information

  • 1The Malaria Centre, Imperial College London, South Kensington, London SW7 2AZ, UK. r.sinden@imperial.ac.uk

Abstract

Since 2010 two global reviews of malaria research have recognized that local elimination and eradication of Plasmodium parasites are key drivers for further experimentation. To achieve these ambitious objectives it is universally recognized we must reduce malaria transmission through the mosquito vectors. A plethora of new laboratory assays are being developed to interrogate malaria transmission from the gametocyte to the sporozoite stage: assays that augment well-established field protocols to determine the entomological inoculation rate. However, the diverse readouts of these assays are not directly comparable. Here we attempt to identify the utility of each assay and provide rational frameworks by which to compare the impacts recorded by the diverse methodologies.

Copyright © 2012 Elsevier Ltd. All rights reserved.

PMID:
22980759
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk