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Dev Cell. 2012 Sep 11;23(3):454-6. doi: 10.1016/j.devcel.2012.08.015.

A ubiquitin-binding rhomboid protease aimed at ERADication.

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  • 1Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, 1050 Boyles Street, Frederick, MD 21701, USA.


Proteins are degraded from the ER by endoplasmic reticulum-associated degradation (ERAD). In a recent issue of Molecular Cell, Fleig et al. (2012) describe a role for a ubiquitin-binding rhomboid protease, RHBDL4, in degradation of select ERAD substrates. These findings and the significance of rhomboids and other intramembrane proteases are discussed.

Copyright © 2012 Elsevier Inc. All rights reserved.

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