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J Virol. 2012 Dec;86(23):13081-4. doi: 10.1128/JVI.01741-12. Epub 2012 Sep 12.

Long-term nonprogressor and elite controller patients who control viremia have a higher percentage of methylation in their HIV-1 proviral promoters than aviremic patients receiving highly active antiretroviral therapy.

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  • 1Fundación de Investigación Biomédica, Hospital Carlos III, Madrid, Spain.

Abstract

Several factors are involved in the control of HIV transcription/replication, including epigenetic modifications at the promoter level. Analysis of the HIV long terminal repeat (LTR) methylation status in infected patients controlling viremia is scarce. Herein, we show a higher degree of DNA methylation in the 5'-LTR of long-term nonprogressor and elite controller (LTNP/EC) versus progressor patients and a positive correlation with time of infection, indicating a certain contribution of HIV LTR silencing in reducing the number of replicating viruses which may account for a delayed progression.

PMID:
22973038
[PubMed - indexed for MEDLINE]
PMCID:
PMC3497688
Free PMC Article
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