Arch Biochem Biophys. 1990 Jan;276(1):278-84.

A rapid redistribution of the transferrin receptor to the cell surface of HL-60 cells and K562 cells upon treatment with dimethyl sulfoxide due to slowing of endocytosis.

Source

Department of Biology, Syracuse University, New York 13244-1220.

Abstract

Treatment of two human leukemia cell lines with 1.25% dimethyl sulfoxide at 37 degrees C results in a rapid increase in the number of transferrin receptors on the cell surface detected by fluorescein-labeled anti-transferrin receptor antibodies. Both HL-60 cells, a human myeloid cell line, and K562 cells, a human erythroid-myeloid cell line, showed a 25-65% increase in cell surface transferrin binding in parallel experiments. Scatchard plot analysis of the data indicates that the number of receptors increases while the affinity of transferrin for the receptor remains the same. This rapid increase in the number of receptors at the cell surface appears to be due to a slowing of endocytosis rather than an increase in externalization of the receptor.

PMID:: 2297227; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Supplemental Content

Related citations

The effect of lead on iron uptake from transferrin in human erythroleukemia (K562) cells. [Biometals. 1993]
The effect of lead on iron uptake from transferrin in human erythroleukemia (K562) cells.
Kohno H, Taketani S, Tokunaga R. Biometals. 1993 Summer; 6(2):77-83.
Microtubule inhibitors differentially affect translational movement, cell surface expression, and endocytosis of transferrin receptors in K562 cells. [J Cell Physiol. 1994]
Microtubule inhibitors differentially affect translational movement, cell surface expression, and endocytosis of transferrin receptors in K562 cells.
Thatte HS, Bridges KR, Golan DE. J Cell Physiol. 1994 Aug; 160(2):345-57.
Modulation of the transferrin receptor during DMSO-induced differentiation in HL-60 cells. [Exp Cell Res. 1988]
Modulation of the transferrin receptor during DMSO-induced differentiation in HL-60 cells.
Enns CA, Mulkins MA, Sussman H, Root B. Exp Cell Res. 1988 Jan; 174(1):89-97.
Review Structure-function analysis of the human transferrin receptor: effects of anti-receptor monoclonal antibodies on tumor growth. [Curr Stud Hematol Blood Transfus. 1991]
Review Structure-function analysis of the human transferrin receptor: effects of anti-receptor monoclonal antibodies on tumor growth.
Trowbridge IS, Collawn J, Jing S, White S, Esekogwu V, Stangel M. Curr Stud Hematol Blood Transfus. 1991; (58):139-47.
Review Endocytotic processes in the differentiable intestinal cell line HT29. [Prog Clin Biol Res. 1990]
Review Endocytotic processes in the differentiable intestinal cell line HT29.
Huet C, Godefroy O, Ibarra C, Dautry-Varsat A, Louvard D. Prog Clin Biol Res. 1990; 343:213-35.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Recent activity

Clear Turn Off Turn On

A rapid redistribution of the transferrin receptor to the cell surface of HL-60 ...
A rapid redistribution of the transferrin receptor to the cell surface of HL-60 cells and K562 cells upon treatment with dimethyl sulfoxide due to slowing of endocytosis.
Arch Biochem Biophys. 1990 Jan ;276(1):278-84.

PubMed
Pyrococcus horikoshii sp. nov., a hyperthermophilic archaeon isolated from a hyd...
Pyrococcus horikoshii sp. nov., a hyperthermophilic archaeon isolated from a hydrothermal vent at the Okinawa Trough.
Extremophiles. 1998 May ;2(2):123-30.

PubMed
Smooth-muscle tumors of the vulva. A clinicopathological study of 25 cases and r...
Smooth-muscle tumors of the vulva. A clinicopathological study of 25 cases and review of the literature.
Am J Surg Pathol. 1996 Jul ;20(7):779-93.

PubMed
Comparative assessment of pediatric intensive care in Moscow, the Russian Federa...
Comparative assessment of pediatric intensive care in Moscow, the Russian Federation: a prospective, multicenter study.
Crit Care Med. 1996 Aug ;24(8):1403-7.

PubMed
Interactions of components of human rhinovirus type 2 with Hela cells.
Interactions of components of human rhinovirus type 2 with Hela cells.
Virology. 1973 Feb ;51(2):270-8.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

A rapid redistribution of the transferrin receptor to the cell surface of HL-60 cells and K562 cells upon treatment with dimethyl sulfoxide due to slowing of endocytosis.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

Supplemental Content

Related citations

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information