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Ann Intern Med. 1990 Feb 1;112(3):182-6.

Abdominal obesity and breast cancer risk.

Author information

  • 1H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.

Erratum in

  • Ann Intern Med 1990 May 15;112(10):798.

Abstract

STUDY OBJECTIVE:

To determine if body fat distribution affects breast cancer risk.

DESIGN:

Prospective case-control study.

PATIENTS:

The anthropometric measurements of 216 consecutively and newly diagnosed women with invasive carcinoma of the breast were compared with those of 432 age-matched controls. The anthropometric measurements taken were abdomen, thigh, suprailiac, biceps, triceps, subscapular, and midaxillary skinfolds; waist and hip circumference; and weight and height. Women between 25 and 83 years of age were included in the study.

RESULTS:

Patients with breast cancer had a significantly greater waist:hip circumference ratio than controls (P less than 0.001) and a significantly greater suprailiac:thigh skinfold ratio (P less than 0.001). The relative risk for breast cancer increased with increasing waist:hip circumference ratio (less than 0.73 = 1.00; 0.73 to 76 = 1.90; 0.77 to 0.80 = 2.83; greater than 0.80 = 6.46) and with suprailiac:thigh skinfold ratio (less than 0.42 = 1.00; 0.42 to 0.56 = 1.85; 0.57 to 0.71 = 2.25; greater than 0.71 = 5.85). At other sites of upper body obesity, such as the biceps and triceps, skinfolds were significantly greater in patients with breast cancer.

CONCLUSION:

Although obese women are at slightly higher risk for developing breast cancer, women with android obesity are a segment of obese women who appear to be at a significantly higher risk for developing breast cancer.

Comment in

PMID:
2297194
[PubMed - indexed for MEDLINE]
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