Omentin-1, visfatin and adiponectin levels in relation to bone mineral density in Iranian postmenopausal women

Bone. 2012 Nov;51(5):876-81. doi: 10.1016/j.bone.2012.08.117. Epub 2012 Aug 19.

Abstract

The bone and fat interface is implicated in the pathogenesis of postmenopausal osteoporosis. The association between circulating omentin-1 levels and bone mineral density (BMD) in postmenopausal women has never been assessed. A total of 382 healthy postmenopausal women were randomly selected. Omentin-1, visfatin, adiponectin, the receptor activator of nuclear factor-κB ligand (RANKL), osteoprotegerin, high sensitivity C-reactive protein, degradation products of C-terminal telopeptides of type I collagen, and osteocalcin were measured by highly specific enzyme-linked immunosorbent assay methods. BMD was determined for the lumbar spine (L2-L4) and the proximal femur using dual-energy X-ray absorptiometry. In multivariable-adjusted linear regression, serum omentin-1 levels were inversely correlated with BMD at the lumbar spine (β=-0.11, p=0.020). In multiple regression analyses, serum visfatin and adiponectin levels were not significantly correlated with BMD at different skeletal sites after controlling for age, body mass index, and bone-related markers. However, the highest quartile of adiponectin compared to the lowest quartile, after adjusting for potential confounders, revealed an inverse association with BMD in the lumbar spine (β=-0.19, p=0.010). In conclusion, circulating omentin-1 levels had an inverse correlation with BMD at the lumbar spine in Iranian postmenopausal women. To further understand the role of omentin-1 in bone and mineral metabolism, large-scale longitudinal studies focusing on BMD and osteoporotic fractures are warranted.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Absorptiometry, Photon
  • Adiponectin / blood*
  • Aged
  • Aged, 80 and over
  • Bone Density / physiology
  • Cytokines / blood*
  • Female
  • GPI-Linked Proteins / blood
  • Humans
  • Iran
  • Lectins / blood*
  • Middle Aged
  • Nicotinamide Phosphoribosyltransferase / blood*
  • Osteoporosis, Postmenopausal / blood*
  • Osteoporosis, Postmenopausal / metabolism
  • Postmenopause / blood

Substances

  • ADIPOQ protein, human
  • Adiponectin
  • Cytokines
  • GPI-Linked Proteins
  • ITLN1 protein, human
  • Lectins
  • Nicotinamide Phosphoribosyltransferase