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FEBS Lett. 2012 Oct 19;586(20):3608-12. doi: 10.1016/j.febslet.2012.08.003. Epub 2012 Aug 9.

MiR-136 promotes apoptosis of glioma cells by targeting AEG-1 and Bcl-2.

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  • 1Key Laboratory of Tropical Disease Control, Sun Yat-Sen University, Ministry of Education, Guangzhou, Guangdong, China.

Abstract

MicroRNAs have the capacity to coordinately repress multiple target genes and interfere with biological functions of the cell, such as proliferation and apoptosis. Here we report that miR-136 is downregulated in human glioma, and that the miRNA promotes apoptosis of glioma cells induced by chemotherapy. Two anti-apoptotic genes, AEG-1 and Bcl-2, are identified as targets of miR-136, and restoration of AEG-1 or Bcl-2 expression suppresses miR-136-enhanced apoptosis. Therefore, miR-136 might play a tumor-suppressive role in human glioma and thereby might represent a potential therapeutic strategy.

Copyright © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

PMID:
22967897
[PubMed - indexed for MEDLINE]
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