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Pediatr Blood Cancer. 2013 Jan;60(1):146-8. doi: 10.1002/pbc.24284. Epub 2012 Sep 7.

Clinical, histologic, and genetic features of mesothelioma in a 7-year-old child.

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  • 1Department of Pediatrics and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.

Abstract

Malignant mesothelioma (MM) is a highly aggressive malignancy that is extremely rare in children. This case report documents a 7-year-old male without previous asbestos exposure with peritoneal MM that initially responded to chemotherapy with cisplatin and gemcitabine but ultimately metastasized to his chest. He was diagnosed with MM based on histology, extensive immunohistochemical analyses, and an elevated serum CA-125 level. Cytogenetics and comparative genomic hybridization (CGH) analysis of his tumor identified a single extra copy number of chromosome 11 with few other changes noted.

Copyright © 2012 Wiley Periodicals, Inc.

PMID:
22961710
[PubMed - indexed for MEDLINE]
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