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Curr Opin Cell Biol. 2012 Dec;24(6):784-92. doi: 10.1016/j.ceb.2012.08.010. Epub 2012 Sep 7.

Cellular reprogramming: a small molecule perspective.

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  • 1Gladstone Institute of Cardiovascular Disease, Department of Pharmaceutical Chemistry, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA.

Abstract

The discovery that somatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) by the expression of a few transcription factors has attracted enormous interest in biomedical research and the field of regenerative medicine. iPSCs nearly identically resemble embryonic stem cells (ESCs) and can give rise to all cell types in the body, and thus have opened new opportunities for personalized regenerative medicine and new ways of modeling human diseases. Although some studies have raised concerns about genomic stability and epigenetic memory in the resulting cells, better understanding and control of the reprogramming process should enable enhanced efficiency and higher fidelity in reprogramming. Therefore, small molecules regulating reprogramming mechanisms are valuable tools to probe the process of reprogramming and harness cell fate transitions for various applications.

Copyright © 2012 Elsevier Ltd. All rights reserved.

PMID:
22959962
[PubMed - indexed for MEDLINE]
PMCID:
PMC3790462
Free PMC Article

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