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Genome Res. 2012 Sep;22(9):1602-11. doi: 10.1101/gr.146506.112.

What does our genome encode?

Author information

  • 1Departments of Genome Sciences and Medicine, University of Washington School of Medicine, Seattle, Washington 98195, USA. jstam@u.washington.edu

Abstract

In its first production phase, The ENCODE Project Consortium (ENCODE) has generated thousands of genome-scale data sets, resulting in a genomic "parts list" that encompasses transcripts, sites of transcription factor binding, and other functional features that now number in the millions of distinct elements. These data are reshaping many long-held beliefs concerning the information content of the human and other complex genomes, including the very definition of the gene. Here I discuss and place in context many of the leading findings of ENCODE, as well as trends that are shaping the generation and interpretation of ENCODE data. Finally, I consider prospects for the future, including maximizing the accuracy, completeness, and utility of ENCODE data for the community.

PMID:
22955972
[PubMed - indexed for MEDLINE]
PMCID:
PMC3431477
Free PMC Article
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