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Chembiochem. 2012 Oct 15;13(15):2200-3. doi: 10.1002/cbic.201200378. Epub 2012 Sep 5.

Preparative, in vitro biocatalysis of triketide lactone chiral building blocks.

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  • 1Institute for Cellular and Molecular Biology, University of Texas at Austin, 1 University Station, A4800, Austin, TX 78712, USA.


PKS biocatalysis: The terminal module of erythromycin synthase was used for the in vitro production of chiral triketide lactones. Combining cofactor regeneration, substrate truncation, and enzymatic promiscuity afforded a scalable strategy to generate these molecules from abundant racemic and achiral precursors. The described biocatalytic platform thus facilitates the application and study of enzymes within PKS modules.

Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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