Format

Send to:

Choose Destination
See comment in PubMed Commons below
Clin Orthop Surg. 2012 Sep;4(3):234-41. doi: 10.4055/cios.2012.4.3.234. Epub 2012 Aug 14.

Effect of combined sex hormone replacement on bone/cartilage turnover in a murine model of osteoarthritis.

Author information

  • 1Department of Orthopaedic Surgery, Seoul Veterans Hospital, Seoul, Korea.

Abstract

BACKGROUND:

Estrogens act on estrogen receptors distributed in articular cartilages, synovial membrane, and ligaments, which are thought to be related with degenerative changes. Meanwhile, progesterone is known to have a weak anabolic action on bone formation This study evaluates the effects of estrogen and progesterone hormone on bone/cartilage turnover in ovariectomized (OVX) rats.

METHODS:

Thirty-five 7-month-old female Sprague-Dawley rats were randomly divided into 5 groups and then ovariectomized bilaterally except the sham control group. The first and the second group acting as controls did not receive hormonal therapy, the third group received estrogen, the fourth group received progesterone, and the fifth group received combination of both hormones 10 weeks after surgery. Evaluations were done using the serum levels of cartilage oligomeric matrix protein (COMP) for cartilage turnover, collagen type I C-telopeptide (CTX-1) and osteocalcin (OC) for bone turnover at 11, 15, 19 weeks after OVX and histology using the Osteoarthritis Research Society International (OARSI) osteoarthritis (OA) cartilage histopathology assessment system.

RESULTS:

Significantly less cartilage degradation (decreased levels of COMP) was found in the combined hormone treated group in comparison with OVX group. Similarly, both hormonal treatment resulted in increased bone formation and decreased bone resorption i.e., a low overall bone turnover status (decrease in the serum OC and CTX-1 levels).

CONCLUSIONS:

Combined estrogen and progesterone therapy was found to be convincing in terms of reducing the severity of OA in this experimental model.

KEYWORDS:

Cartilage oligomeric matrix protein; Collagen type I C-telopeptide; Estrogen; Osteocalcin; Progesterone

PMID:
22949956
[PubMed - indexed for MEDLINE]
PMCID:
PMC3425655
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for The Korean Orthopaedic Association Icon for PubMed Central
    Loading ...
    Write to the Help Desk