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Antimicrob Agents Chemother. 2012 Nov;56(11):6037-40. doi: 10.1128/AAC.01320-12. Epub 2012 Sep 4.

Regulation of RamA by RamR in Salmonella enterica serovar Typhimurium: isolation of a RamR superrepressor.

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  • 1Antimicrobial Agents Research Group, School of Immunity and Infection and Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom.

Abstract

RamA is a transcription factor involved in regulating multidrug resistance in Salmonella enterica serovar Typhimurium SL1344. Green fluorescent protein (GFP) reporter fusions were exploited to investigate the regulation of RamA expression by RamR. We show that RamR represses the ramA promoter by binding to a palindromic sequence and describe a superrepressor RamR mutant that binds to the ramA promoter sequence more efficiently, thus exhibiting a ramA inactivated phenotype.

PMID:
22948865
[PubMed - indexed for MEDLINE]
PMCID:
PMC3486581
Free PMC Article

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