Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Nat Rev Neurosci. 2012 Oct;13(10):727-36. doi: 10.1038/nrn3319. Epub 2012 Sep 5.

New neurons for 'survival of the fittest'.

Author information

  • Center for Regenerative Therapies Dresden and the German Center for Neurodegenerative Diseases, Fetscherstra├če 105, 01307 Dresden, Germany. gerd.kempermann@crt-dresden.de

Abstract

Adult neurogenesis is often considered an archaic trait that has undergone a 'phylogenetic reduction' from amphibian ancestors to humans. However, adult neurogenesis in the hippocampal dentate gyrus might actually be a late-evolved trait. In non-mammals, adult hippocampal neurogenesis is not restricted to the equivalents of the dentate gyrus, which also show different connectivity and functionality compared to their mammalian counterpart. Moving actively in a changing world and dealing with novelty and complexity regulate adult neurogenesis. New neurons might thus provide the cognitive adaptability to conquer ecological niches rich with challenging stimuli.

Comment in

PMID:
22948073
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk