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Trends Microbiol. 2012 Nov;20(11):558-66. doi: 10.1016/j.tim.2012.08.002. Epub 2012 Aug 31.

Tricks an IRES uses to enslave ribosomes.

Author information

  • Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. sunnie@uab.edu

Abstract

In eukaryotes, mRNAs are primarily translated through a cap-dependent mechanism whereby initiation factors recruit the 40S ribosomal subunit to a cap structure at the 5' end of the mRNA. However, some viral and cellular messages initiate protein synthesis without a cap. They use a structured RNA element termed an internal ribosome entry site (IRES) to recruit the 40S ribosomal subunit. IRESs were discovered over 20 years ago, but only recently have studies using a model IRES from dicistroviruses expanded our understanding of how a 3D RNA structure can capture and manipulate the ribosome to initiate translation.

Copyright © 2012 Elsevier Ltd. All rights reserved.

PMID:
22944245
[PubMed - indexed for MEDLINE]
PMCID:
PMC3479354
Free PMC Article

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