Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Prim Care Companion CNS Disord. 2012;14(2). pii: PCC.11m01220. doi: 10.4088/PCC.11m01220. Epub 2012 Mar 15.

Cognitive-behavioral therapy for the treatment of depression and adherence in patients with type 1 diabetes: pilot data and feasibility.

Author information

  • 1Department of Psychology, Wells College, Aurora, New York (Dr Markowitz); Ferkauf Graduate School of Psychology and Albert Einstein College of Medicine, Yeshiva University, New York, NewYork (Dr Gonzalez); and Diabetes Research Center (Ms Delahanty) and Behavioral Medicine Service (Mr Carper and Dr Safren), Massachusetts General Hospital and Harvard Medical School, Boston.

Abstract

OBJECTIVE:

Depression is one of the most common psychological problems affecting individuals with type 1 diabetes, and it is associated with treatment nonadherence and worse clinical outcomes. The research on treating depression or nonadherence in adults with type 1 diabetes is limited. We adapted an evidence-supported treatment, individual cognitive-behavioral therapy for adherence and depression (CBT-AD), for type 1 diabetes and examined its feasibility, acceptability, and potential for an effect.

METHOD:

The pilot study included 9 patients with a DSM-IV diagnosis of major depression, dysthymia, or residual depressive symptoms despite treatment with an antidepressant; a diagnosis of type 1 diabetes per patient self-report; and a glycosylated hemoglobin A1c (HbA1c) level of 8.0% or greater. Patients were referred by their diabetes care providers to a behavioral medicine specialty setting and received 10 to 12 sessions of CBT-AD. Main outcome measures included percent of eligible participants who enrolled in the study, session attendance, independently-rated Montgomery-Asberg Depression Rating Scale (MADRS) score, self-reported adherence to diabetes care activities, and adherence to self-monitoring of blood glucose levels. Data were collected from June 27, 2008, through March 31, 2010.

RESULTS:

There was a clinically meaningful decrease in depression severity (mean [SD] MADRS score decrease from 26.0 [4.73] to 12.3 [7.37], Cohen d = 2.90), demonstrated improvements in diabetes self-care (increase in blood glucose monitoring from 65.0 [26.72] to 82.7 [22.75], Cohen d = -0.66, and a difference in self-reported percent insulin doses in the past 2 weeks from 77.1 [29.84] to 87.1 [23.6], Cohen d = -0.34), and possible improvement in glycemic control (decrease in HbA1c levels from 9.6 [1.32] to 9.0 [1.04], Cohen d = 0.45).

CONCLUSIONS:

These preliminary results provide evidence for the acceptability, feasibility, and potential utility of CBT-AD for patients with type 1 diabetes and depression.

TRIAL REGISTRATION:

clinicaltrials.gov Identifier: NCT01527981.

PMID:
22943030
[PubMed]
PMCID:
PMC3425462
Free PMC Article

Images from this publication.See all images (2)Free text

Figure 1.
Figure 2
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Dartmouth Journal Services Icon for PubMed Central
    Loading ...
    Write to the Help Desk