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Clin Immunol. 2012 Oct;145(1):82-8. doi: 10.1016/j.clim.2012.07.015. Epub 2012 Aug 4.

IL-2 controls trafficking receptor gene expression and Th2 response for skin and lung inflammation.

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  • 1Center for Immunity, Inflammation and Regenerative Medicine and Division of Rheumatology and Immunology, Department of Medicine, University of Virginia, Charlottesville, VA 22908-0133, USA.


Both Il2(-/-) mice and Scurfy (Sf) mutant mice that are deficient in FoxP3, develop multi-organ inflammation but only the latter display severe skin and lung inflammation. In contrast, Sf.Il2(-/-) double mutant mice do not display skin inflammation and markedly reduced lung inflammation. In this review, we summarize our recent findings based on microarray, q-PCR and functional studies of 10 Sf double mutant mice. These studies revealed novel pro-inflammatory functions of IL-2 in regulating inflammation in an organ-specific manner. IL-2 exerts its "organ-specific" pro-inflammatory function by regulating the migration and retention of CD4(+) T-cells (both Th1 and Th2) specifically to the skin and lung. In addition, IL-2 is also required for regulating the Th2 cytokine response during T-cell activation. Further studies on these IL-2-regulated genes will help in identifying novel targets for intervention in inflammatory diseases of skin and lung.

Copyright © 2012 Elsevier Inc. All rights reserved.

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