Format

Send to:

Choose Destination
See comment in PubMed Commons below
Eur J Intern Med. 2012 Oct;23(7):594-8. doi: 10.1016/j.ejim.2012.03.016. Epub 2012 Apr 21.

The association of Raynaud's syndrome with cisplatin-based chemotherapy - a meta-analysis.

Author information

  • 1Department of Biometry and Clinical Epidemiology, Charit√© Universit√§tsmedizin Berlin, Berlin, Germany. melvin.mohokum@charite.de

Abstract

BACKGROUND:

Vasospastic disorders of the digital circulation such as the Raynaud's syndrome (RS) are known side-effects of treatment of cisplatin-based chemotherapy. The prevalence of RS in patients during treatment with cisplatin-based chemotherapy is not well-defined.

OBJECTIVE:

The objective of this paper was to assess the prevalence of RS in patients receiving cisplatin-based chemotherapy - a meta-analysis of published data was performed.

MATERIAL AND METHODS:

The PubMed database of the National Library of Medicine and ISI Web of Knowledge was used for studies dealing with RS and patients receiving cisplatin-based chemotherapy. The studies provided sufficient data to estimate the prevalence of RS in patients receiving cisplatin-based chemotherapy. A forest plot was determined by the revealed prevalences. Statistical analysis was based on methods for a random effects meta-analysis and a finite mixture model for proportions. Publication bias was investigated with the linear regression test (Egger's method). A meta-regression was conducted by the year of publication and latitude.

RESULTS:

24 eligible studies, contributing data on 2749 subjects, were included in this meta-analysis. For RS in patients receiving cisplatin-based chemotherapy a pooled prevalence of 24% and 95% CI (0.175, 0.313) was obtained. A mixture model analysis found four latent classes. Statistically, publication bias was not present (p-value 0.74). The meta-regression indicated that the odds ratio increased when the latitude increased, too (p-value 0.011).

CONCLUSION:

Despite some heterogeneity there is a possible indication of an association between RS and patients receiving cisplatin-based chemotherapy.

Copyright © 2012 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

PMID:
22939802
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk