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Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Feb;117(2):e74-8. doi: 10.1016/j.oooo.2012.04.022. Epub 2012 Aug 30.

Tacrolimus on Kimura's disease: a case report.

Author information

  • 1Oral and Maxillofacial Surgery Department of the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
  • 2Oral and Maxillofacial Surgery Department of the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. Electronic address: shuxindaddy@sohu.com.

Abstract

OBJECTIVE:

We report preliminary results of an ongoing study that assesses the efficacy of tacrolimus on Kimura's disease (KD).

STUDY DESIGN:

A patient with refractory KD after surgery and treatment with prednisone was treated with tacrolimus. Tacrolimus (FK-506) was administered at an initial dosage of 1 mg every 12 hours, and FK-506 concentration in the blood was monitored monthly. FK-506 blood concentration was controlled within 5 to 15 μg/L. After 6 months, the dosage of tacrolimus was reduced to 0.5 mg daily for another 2 months and then treatment was stopped.

RESULTS:

Swelling of the bilateral salivary glands disappeared within the first week. No serious side effects were noted and the disease has not recurred in the 2 years of follow-up.

CONCLUSIONS:

Tacrolimus may be an effective treatment for patients with KD, but more research is needed to determine its long-term efficacy and safety as well as its mechanism of action.

Copyright © 2014 Elsevier Inc. All rights reserved.

PMID:
22939325
[PubMed - in process]
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