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J Med Case Rep. 2012 Aug 31;6(1):263. doi: 10.1186/1752-1947-6-263.

Successful management of allergy to the insulin excipient metacresol in a child with type 1 diabetes: a case report.

Author information

  • 1Department of Women's and Children's Health, University of Otago, Dunedin, 9054, New Zealand. ben.wheeler@otago.ac.nz.

Abstract

INTRODUCTION:

Insulin allergy to human insulin preparations during the treatment of diabetes is suggested to occur at rates ranging from <1.0% to 2.4%. These reactions vary from mild localized reactions, which resolve with repeated exposure, to life-threatening anaphylaxis and death. The management of persistent insulin allergy in type 1 diabetes mellitus is particularly complicated because ongoing treatment with insulin is essential.

CASE PRESENTATION:

We present the case of a 12-year-old Caucasian girl with localized allergy to the insulin excipient metacresol, and the subsequent desensitization therapy using continuous subcutaneous insulin infusion with simultaneous intravenous insulin infusion.

CONCLUSIONS:

This is the first documented case of allergy to the metacresol component of insulin in the pediatric type 1 diabetes literature. We describe an approach to diagnosis and management of metacresol allergy in type 1 diabetes.

PMID:
22937994
[PubMed]
PMCID:
PMC3469394
Free PMC Article

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