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J Am Soc Nephrol. 2012 Oct;23(10):1631-4. Epub 2012 Aug 30.

Mechanisms of anemia in CKD.

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  • 1Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.


Anemia is a common feature of CKD associated with poor outcomes. The current management of patients with anemia in CKD is controversial, with recent clinical trials demonstrating increased morbidity and mortality related to erythropoiesis stimulating agents. Here, we examine recent insights into the molecular mechanisms underlying anemia of CKD. These insights hold promise for the development of new diagnostic tests and therapies that directly target the pathophysiologic processes underlying this form of anemia.

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