Warning: The NCBI web site requires JavaScript to function. more...
Generate a file for use with external citation management software.
TRON-Translational Oncology at the University Medical Center Mainz; Mainz, Germany.
Next generation sequencing enables identification of immunogenic tumor mutations targetable by individualized vaccines. In the B16F10 melanoma system as pre-clinical proof-of-concept model, we found a total of 563 non-synonymous expressed somatic mutations. Of the mutations we tested, one third were immunogenic. Immunization conferred in vivo tumor control, qualifying mutated epitopes as source for effective vaccines.
Images from this publication.See all images (1)Free text
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on