Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Oncoimmunology. 2012 Aug 1;1(5):768-769.

Targeting the tumor mutanome for personalized vaccination therapy.

Author information

  • 1TRON-Translational Oncology at the University Medical Center Mainz; Mainz, Germany.

Abstract

Next generation sequencing enables identification of immunogenic tumor mutations targetable by individualized vaccines. In the B16F10 melanoma system as pre-clinical proof-of-concept model, we found a total of 563 non-synonymous expressed somatic mutations. Of the mutations we tested, one third were immunogenic. Immunization conferred in vivo tumor control, qualifying mutated epitopes as source for effective vaccines.

PMID:
22934277
[PubMed]
PMCID:
PMC3429589
Free PMC Article

Images from this publication.See all images (1)Free text

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for PubMed Central
    Loading ...
    Write to the Help Desk