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J Bone Joint Surg Br. 2012 Sep;94(9):1154-9. doi: 10.1302/0301-620X.94B9.28611.

The local infiltration of analgesia following total knee replacement: a review of current literature.

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  • 1Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK. dmrgibbs@yahoo.co.uk


Controversy remains regarding the optimal post-operative analgesic regimen following total knee replacement. A delicate balance is required between the provision of adequate pain relief and early mobilisation. By reviewing 29 randomised trials we sought to establish whether local infiltration of analgesia directly into the knee during surgery provides better pain relief and a more rapid rehabilitation. Although we were able to conclude that local infiltration can provide improved post-operative pain relief, and to suggest the most promising technique of administration, there is no evidence that it reduces hospital stay.

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