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Clin Chest Med. 2012 Sep;33(3):473-84. doi: 10.1016/j.ccm.2012.06.009. Epub 2012 Jul 25.

Asthma: a chronic infectious disease?

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  • 1Section of Respiratory Diseases, Department of Medical Sciences, Centro per lo Studio delle Malattie Infiammatorie Croniche delle Vie Aeree e Patologie Fumo Correlate dell'Apparato Respiratorio, University of Ferrara, via Savonarola 9, 44121, Ferrara, Italy.

Abstract

There are increasing data to support the "hygiene" and "microbiota" hypotheses of a protective role of infections in modulating the risk of subsequent development of asthma. There is less evidence that respiratory infections can actually cause the development of asthma. There is some evidence that rhinovirus respiratory infections are associated with the development of asthma, particularly in childhood, whereas these infections in later life seem to have a weaker association with the development of asthma. The role of bacterial infections in chronic asthma remains unclear. This article reviews the available evidence indicating that asthma may be considered as a chronic infectious disease.

Copyright © 2012 Elsevier Inc. All rights reserved.

PMID:
22929096
[PubMed - indexed for MEDLINE]
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