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Oxid Med Cell Longev. 2012;2012:634674. doi: 10.1155/2012/634674. Epub 2012 Jul 2.

Kluyveromyces lactis: a suitable yeast model to study cellular defense mechanisms against hypoxia-induced oxidative stress.

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  • 1Departamento de Bioloxía Celular e Molecular, Facultade de Ciencias, Universidade da Coruña, Coruña, Spain.


Studies about hypoxia-induced oxidative stress in human health disorders take advantage from the use of unicellular eukaryote models. A widely extended model is the fermentative yeast Saccharomyces cerevisiae. In this paper, we describe an overview of the molecular mechanisms induced by a decrease in oxygen availability and their interrelationship with the oxidative stress response in yeast. We focus on the differential characteristics between S. cerevisiae and the respiratory yeast Kluyveromyces lactis, a complementary emerging model, in reference to multicellular eukaryotes.

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