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Dermatoendocrinol. 2012 Apr 1;4(2):128-36. doi: 10.4161/derm.20361.

Does vitamin D deficiency contribute to erectile dysfunction?

Abstract

Erectile dysfunction (ED) is a multifactorial disease, and its causes can be neurogenic, psychogenic, hormonal and vascular. ED is often an important indicator of cardiovascular disease (CVD) and a powerful early marker for asymptomatic CVD. Erection is a vascular event, and ED is often a vascular disease caused by endothelial damage and subsequent inhibition of vasodilation. We show here that risk factors associated with a higher CVD risk also associate with a higher ED risk. Such factors include diabetes mellitus, hypertension, arterial calcification and Inflammation in the vascular endothelium. Vitamin D deficiency is one of several dynamics that associates with increased CVD risk, but to our knowledge, it has not been studied as a possible contributor to ED. Here we examine research linking ED and CVD and discuss how vitamin D influences CVD and its classic risk factors-factors that also associate to increased ED risk. We also summarize research indicating that vitamin D associates with reduced risk of several nonvascular contributing factors for ED. We conclude that VDD contributes to ED. This hypothesis should be tested through observational and intervention studies.

KEYWORDS:

calcification; diabetes; erectile dysfunction; hypertension; inflammation; nitric oxide; peripheral arterial disease; vascular diseases; vasodilation; vitamin D

PMID:
22928068
[PubMed]
PMCID:
PMC3427191
Free PMC Article
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