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Neuroimage. 2013 Jan 1;64:240-56. doi: 10.1016/j.neuroimage.2012.08.052. Epub 2012 Aug 25.

An improved framework for confound regression and filtering for control of motion artifact in the preprocessing of resting-state functional connectivity data.

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  • 1Department of Psychiatry, University of Pennsylvania, Philadelphia PA 19104, USA. sattertt@upenn.edu

Abstract

Several recent reports in large, independent samples have demonstrated the influence of motion artifact on resting-state functional connectivity MRI (rsfc-MRI). Standard rsfc-MRI preprocessing typically includes regression of confounding signals and band-pass filtering. However, substantial heterogeneity exists in how these techniques are implemented across studies, and no prior study has examined the effect of differing approaches for the control of motion-induced artifacts. To better understand how in-scanner head motion affects rsfc-MRI data, we describe the spatial, temporal, and spectral characteristics of motion artifacts in a sample of 348 adolescents. Analyses utilize a novel approach for describing head motion on a voxelwise basis. Next, we systematically evaluate the efficacy of a range of confound regression and filtering techniques for the control of motion-induced artifacts. Results reveal that the effectiveness of preprocessing procedures on the control of motion is heterogeneous, and that improved preprocessing provides a substantial benefit beyond typical procedures. These results demonstrate that the effect of motion on rsfc-MRI can be substantially attenuated through improved preprocessing procedures, but not completely removed.

Copyright © 2012 Elsevier Inc. All rights reserved.

PMID:
22926292
[PubMed - indexed for MEDLINE]
PMCID:
PMC3811142
Free PMC Article

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