Format

Send to:

Choose Destination
See comment in PubMed Commons below
Future Med Chem. 2012 Sep;4(13):1751-61. doi: 10.4155/fmc.12.124.

Natural products as a rich source of tau-targeting drugs for Alzheimer's disease.

Author information

  • 1Department of Chemistry & Center for Drug Discovery & Innovation, University of South Florida, FL, USA.

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder and the most common form of dementia, affecting more than 5.4 million people in the USA. Although the cause of AD is not well understood, the cholinergic, amyloid and tau hypotheses were proposed to explain its development. Drug discovery for AD based on the cholinergic and amyloid theories have not been effective. In this article we summarize tau-based natural products as AD therapeutics from a variety of biological sources, including the anti-amyloid agent curcumin, isolated from turmeric, the microtubule stabilizer paclitaxel, from the Pacific Yew Taxus brevifolia, and the Streptomyces-derived Hsp90 inhibitor, geldanamycin. The overlooked approach of clearing tau aggregation will most likely be the next objective for AD drug discovery.

PMID:
22924511
[PubMed - indexed for MEDLINE]
PMCID:
PMC3575183
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon Icon for PubMed Central
    Loading ...
    Write to the Help Desk