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J Virol. 2012 Sep;86(18):10242-3. doi: 10.1128/JVI.01628-12.

Complete genome sequence of Ikoma lyssavirus.

Author information

  • 1Wildlife Zoonoses & Vector-Borne Diseases Research Group, Animal Health & Veterinary Laboratories Agency, Addlestone, Surrey, United Kingdom.

Abstract

Lyssaviruses (family Rhabdoviridae) constitute one of the most important groups of viral zoonoses globally. All lyssaviruses cause the disease rabies, an acute progressive encephalitis for which, once symptoms occur, there is no effective cure. Currently available vaccines are highly protective against the predominantly circulating lyssavirus species. Using next-generation sequencing technologies, we have obtained the whole-genome sequence for a novel lyssavirus, Ikoma lyssavirus (IKOV), isolated from an African civet in Tanzania displaying clinical signs of rabies. Genetically, this virus is the most divergent within the genus Lyssavirus. Characterization of the genome will help to improve our understanding of lyssavirus diversity and enable investigation into vaccine-induced immunity and protection.

PMID:
22923801
[PubMed - indexed for MEDLINE]
PMCID:
PMC3446578
Free PMC Article
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