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Exp Parasitol. 2012 Nov;132(3):327-33. doi: 10.1016/j.exppara.2012.08.004. Epub 2012 Aug 16.

Serum of Babesia rodhaini infected mice down regulates catalase activity of healthy erythrocytes.

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  • 1United Graduate School of Veterinary Science, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.

Abstract

Hemolytic activity for animals infected with various Babesia species is well reported. In this study, we confirmed that serum of Babesia rodhaini-infected mice also showed hemolytic activity. Erythrocytes from non-infected mice were lysed by co-incubation with B. rodhaini-infected serum. Catalase activity of the non-infected target erythrocytes was suppressed after this co-incubation with the hemolytic serum of B. rodhaini-infected mice. Furthermore, serum hemolytic activity was inhibited when target erythrocytes were incubated with hemolytic serum in the presence of exogenous catalase. Our study indicated that hemolytic serum can down-regulate the antioxidant capacity of non-infected healthy erythrocytes, possibly as a result of catalase activity, thereby leading to hemolysis.

Copyright © 2012 Elsevier Inc. All rights reserved.

PMID:
22921498
[PubMed - indexed for MEDLINE]
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