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Immunity. 2012 Aug 24;37(2):196-8. doi: 10.1016/j.immuni.2012.08.007.

Interleukin-22, the guardian of the intestinal stem cell niche?

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  • IMMH, Institute of Medical Microbiology and Hygiene, University of Freiburg, Hermann-Herder-Strasse 11, 79104 Freiburg, Germany. andreas.diefenbach@uniklinik-freiburg.de


Our molecular understanding of how immune cells protect epithelial cells against damage is limited. In this issue of Immunity, Hanash et al. (2012) report that interleukin-22 produced by innate lymphoid cells provides protection to the stem cell niche of the intestinal epithelium.

Copyright © 2012 Elsevier Inc. All rights reserved.

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